UJI EFEK JUS TAOGE TERHADAP KADAR KOLESTEROL TIKUS (Rattus norvegicus) JANTAN HIPERLIPIDEMIA

Sukmawati Sukmawati, A. Ririn Perawanti Asgap

Abstract


The test effect of Taoge Juice on Cholesterol Level of Rat (Rattus norvegicus) Male Hyperlipidemia.This research purpose to know and to fix the concentration of Taoge Juice which have hypolipidemia effect at rat (Rattus norvegicus) male, that administered orally has been conducted. This research used 15 rat male and divided to 5 groups, and each group consist 3 rat male. First group given Na.CMC as control, second group given simvastatin as standard of comparison.The third, fourth and fifth groups given Taoge Juice with 30 %, 60%, and 90 % respectively. This research done by measuring the normal cholesterol level, induced by propiltiurazil and goat lipid and  given by NaCMC, Taoge Juice with 30%, 60%, and 90% concentration and standard of comparison (Simvastatin). This cholesterol level determing by using Human Analyzer. Then do the analyzing data. Besed on analyzed data obtain that control group is significantly (p<0,05) with 30%, 60%, dan 90% group and standard of comparison group. While the group of Taoge Juiceand standard of comparison group not significantly (p>0,05). By analysis of the research result that Taoge Juice have hypolopidemia effect on 30%, 60%, dan 90% concentration.


Keywords


Hyperlipidemia, Taoge Juice, Cholesterol Level, Simvastatin

References


Sánchez-Aranguren LC, Prada CE, Riaño-Medina C. E, Lopez M. Endothelial Dysfunction and Preeclampsia: Role of Oxidative Stress. Frontiers in Physiology 2014;5:372.

Dipiro JT, Talbert RL, Yee GC., Matzke GR, Wells BG, Posey LM. Pharmacotherapy A Pathophysiologic Approach, 8 th Edition. United States of America: The McGraw-Hill Companies Inc. Chapter 28; 2011.

Steyers, Curtis M, Miller F. Endothelial Dysfunction in Chronic Inflammatory Diseases. International Journal of Molecular Sciences 2014;15(7):11324-11349.

Mayes PA, Botham KM. Lipids of Physiologic Significance. In : Murray, RK., Granner, DK., Mayes, PA., and Rodwell, VW. : Harper’s illustrated biochemistry, 26th ed. New York: Mac Graw Hill; 2003.

Barrett KE, Barman SM, Boitano S, Brooks HL. Ganong's Review of Medical Physiology, Twenty-Third Edition. United State: The McGraw-Hill Companies Inc.; 2010.

Amri, Yasirli. Segudang Manfaat Tauge bagi Tubuh (online). Diakses pada 15 Desember 2012.

Ummu. 2011. Kecambah Kacang Hijau Punya Nilai Gizi Tinggi. The Epoch Times. (online). (http://diabetes.com) Diakses 5 April 2013.

Zainuddin M. Metodologi Penelitian: Kefarmasiaan dan Kesehatan. Surabaya: Airlangga University Press;2011.

Parrot EL. Pharmaceutical Technology Fundamental Pharmaceutics. Minnepolis: BurgessPublishing Company;1979.

Mufidah. Aktivitas Antiaterosklerosis Ekstrak Terstandar Klika Ongkea (Mezzetia parviflora becc.) pada Tikus Wistar yang Diberi Asupan Kolesterol (Desertasi) Makassar : Universitas Hasanuddin,; 2011.

Mustofa S, Anindito AA, Pratiwi A, A Putri A, Maulana M. The influence of Piper retrofractum Vahl (Java’s chili) extract towards lipid profile and histology of rats coronary artery with high-fat die. Jurnal Kedokteran 2014;4(7):52-59.

Sulistyowati, Yeny Pengaruh Pemberian Likopen Terhadap Status Antioksidan (Vitamin C, Vitamin E dan Gluthathion Peroksidase) Tikus (Rattus norvegicus galur Sprague Dawley) Hiperkolesterolemik (Tesis). Semarang : Universitas Diponegoro; 2006.

Gunawan G, Sulistia. Farmakologi dan Terapi Edisi V. Jakarta: UI Press.; 2007.




DOI: https://doi.org/10.56711/jifa.v9i2.301

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ISSN: 2085-4714 | e-ISSN: 2502-9444

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Faculty of Pharmacy, Univeristas Muslim Indonesia
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