PROFIL KADAR GLUKOSA DARAH PASIEN DIABETES MELLITUS TIPE 2 YANG MENGGUNAKAN ATORVASTATIN 20 MG DI RUMAH SAKIT MADANI, ANUTAPURA DAN UNDATA PERIODE 2015-2019

Widya Lestari, Alwiyah Mukaddas

Abstract


Atorvastatin is one of the lipophilic statins that can cause diabetes through some mechanisms, such as liphophilic properties, it’s activities to insulin secretion, insulin signaling, and adiponectin levels. The purpose of this research is to know demographic data, profile of when blood sugar levels, and the time needed for atorvastatin to increase blood sugar when type 2 diabetes mellitus patients use atorvastatin for 20 mg. This research is observational descriptive research with retrospective data collection approach by looking at the usage of atorvastatin, with total samples 22 patients obtained from medical record data at Madani hospital, Anutapura and Undata in Palu in the period of 2015-2019. This research result shows that the demographic data of the average age of type 2 diabetes mellitus patients in which complications of dysplidemia that uses atorvastatin for 20 mg are in the age of 45-56 years old, female gender (57.14%), with the last education of Senior High School (38.09%) and occupation as Government Employees (33.33%), the time needed for atorvastatin 20 mg to increase blood sugar is 2 months (the difference is 26.38 mg/dl; percentage 19.52%) and the percentage of highest blood sugar increase is one year, which is 93.91%.


Keywords


Atorvastatin, Glukosa Darah Sewaktu (GDS), DMT2

References


ADA. American Diabetes Association Standards Of Medical Care In Diabetes. Diabetes Care. 2018; 41(9): 2045–2047.

Aiman U, Najmi A, and Khan R. Statin induced diabetes and its clinical implications. Journal of Pharmacology and Pharmacotherapeutics. 2014;5(3):181.

Al-Abri SA, Hayashi S, Thoren KL, Olson KR. Metformin overdose-induced hypoglycemia in the absence of other antidiabetic drugs. Clinical Toxicology. 2013;51(5): 444-447

Atalla MM, Hamed ER, and El-Shami AR. Optimization of a culture medium for increased mevinolin production by Aspergillus terreus strain. Malaysian Journal of Microbiology 2008; 4(2).

Baker WL, Talati R, White CM, and Coleman CI. Differing effect of statins on insulin sensitivity in non-diabetics: A systematic review and meta-analysis. Diabetes Research and Clinical Practice. 2010; 87(1): 98-107.

Carter AA, Gomes T, Camacho X, N Juurlink D, R Shah B, and M Mamdani M. Risk of incident diabetes among patients treated with statins : 2013; population based study. BMJ. 2013; 346:f2610:1-11.

Culver AL, Ockene IS, Balasubramanian R, Olendzki BC, Sepavich DM, Wactawski-Wende J, Ma Y. Statin use and risk of diabetes mellitus in postmenopausal women in the Women’s Health Initiative. Archives of Internal Medicine. 2012;172(2):144–152.

Damayanti L. Diabetes dan Hipertensi Wanita Lebih Berisiko [http://www.herbalitas.com/ diabetes-hipertensiwanita-lebih-beresiko/]. 2010. diakses pada tanggal 22 November 2019.

Saputra EV. Respons Akut Shiatsu dan Refleksi terhadap Kadar Glukosa Darah Penderita Diabetes Melitus Tipe Dua. 2017. Retrieved from journal.student.uny.ac.id/ojs/index.php/ikora/article/download/8808/8467

Gibney MJ, Kearney BM, Arab MJL. Gizi Kesehatan Masyarakat. Jakarta: EGC. 2009.

Hakim DL. Hubungan Tingkat Sosial Ekonomi : Pendidikan, Penghasilan, dan Fasilitas dengan Pencegahan Komplikasi Kronis Pada Penyandang Diabetes Melitus Tipe 2 (Skripsi). Surakarta. Fakultas Ilmu Kesehatan Universitas Muhammadiyah Surakarta, 2018.

Irawan D. Prevalensi dan Faktor Risiko Kejadian Diabetes Melitus Tipe 2 di Daerah Urabn Indonesia. Universitas Indonesia 2010; 1–121. Retrieved from http://lib.ui.ac.id/file?file=digital/20267101-T 28492-Prevalensi dan faktor-full text.pdf

Putra RJS, Achmad A, Pramestutie PH. Kejadian Efek Samping Potensial Terapi Obat Anti Diabetes Pada Pasien Diabetes Melitus Berdasarkan Algoritme Naranjo. Pharmaceutical Journal of Indonesia. 2017; 2(2):45–50.

Kementrian kesehatan Republik Indonesia. Laporan Nasional Riset Kesehatan Dasar 2018. 2018.

Kusnanto K, Sundari PM, Asmoro CP, Arifin H. Hubungan Tingkat Pengetahuan Dan Diabetes Self-Management Dengan Tingkat Stres Pasien Diabetes Melitus Yang Menjalani Diet. Jurnal Keperawatan Indonesia, 2019; 22(1):31–42. https://doi.org/10.7454/jki.v22i1.780

Mihardja, L. Faktor yang Berhubungan dengan Pengendalian Gula Darah pada Penderita Diabetes Mellitus dalam Majalah Kedokteran Indonesia. Jakarta. 2009.

Mutmainah I. Hubungan Kadar Gula Darah dengan Hipertensi Pada Penderita Diabetes Melitus Tipe 2 di Rumah Sakit Umum Daerah Karanganyar (Skripsi). Surakarta. Fakultas Kedokteran Universitas Muhammadiyah Surakarta, 2012.

Navarese EP, Buffon A, Andreotti F, Kozinski M, Welton N, Fabiszak T, Kubica J. Meta-Analysis Of Impact of Different Types And Doses of Statins on New-Onset Diabetes Mellitus. American Journal of Cardiology. 2013; 111(8):1123–1130.

PERKI.Panduan Tatalaksana Dislipidemia. Jakarta. Perhimpunan Dokter Spesialis Kardiovaskular Indonesia, 2017.

Putri RI. Faktor Determinan Nefropati Diabetik pada Penderita Diabetes Melitus di RSUD DR. M. Soewandhie Surabaya. Jurnal Berkala Epidemiologi. 2015;3(1):109–121.

Smeltzer SC, Bare BG. Buku Ajar Kesehatan Medical Bedah, Volume 2, Edisi 8. Jakarta: Buku Kedokteran EGC, 2008.

Stancu C, Sima A. Statins: mechanism of action and effects. J Cell Mol Med. 2001;5(4):378-87.

Sukardji K. Penatalaksanaan Gizi pada Diabetes Melitus, dalam Buku Penatalaksanaan Diabetes Melitus Terpadu (Panduan Penatalaksanaan Diabetes Melitus bagi Dokter dan Edukator). Edisi ke-2, Cetakan ke-7. Jakarta: Balai Penerbit FKUI, 2009.

Suyono, S. Patofisiologi Diabetes Melitus, dalam Buku Penatalaksanaan Diabetes Melitus Terpadu (Panduan Penatalaksanaan Diabetes Melitus bagi Dokter dan Edukator). Edisi ke-2, Cetakan ke-7. Jakarta: Balai Penerbit FKUI, 2009.

Waters DD, Ho JE, Boekholdt SM, Demicco DA, Kastelein JJP, Messig M, Pedersen TR. Cardiovascular event reduction versus new-onset diabetes during atorvastatin therapy: Effect of baseline risk factors for diabetes. Journal of the American College of Cardiology. 2013; 61(2):148-152




DOI: https://doi.org/10.56711/jifa.v12i2.607

Refbacks

  • There are currently no refbacks.


Indexed by:

     

ISSN: 2085-4714 | e-ISSN: 2502-9444

Editor's Address:

Faculty of Pharmacy, Univeristas Muslim Indonesia
2nd Campus of UMI: Jl. Urip Sumoharjo km. 5 , Makassar, South Sulawesi, Indonesia

E-mail: jurnal.farmasi@umi.ac.id

View My Stats