AKTIVITAS ANTIDIABETES DARI TANAMAN FAMILI MYRTACEAE DENGAN INDUKSI ALOKSAN

Yustika Alfani, Siva Hamdani, Hesti Renggana

Abstract


Diabetes mellitus is a metabolic disease characterized by hyperglycemia. This disease occurs due to abnormalities in insulin secretion, insulin work or both. Plants from the myrtaceae family that have been used traditionally as medicine and scientifically known to have various anti-inflammatory, anti-cancer, anti-diarrheal, antibacterial and antidiabetic activities. This review aims to provide information and efforts in the treatment of diabetes from several plants in the Myrtaceae family. The method used in this review is a literature review from various journals published online and I will discuss 8 plants from the myrtaceae family that are induced by alloxan. From the results it is known that of the 8 plants of the myrtaceae family that have been tested using alloxan induction has antidiabetic activity. Syzygium Polyanthum (Wight) is the most potential candidate in reducing blood glucose levels.


Keywords


Alloxan, diabetic, myrtaceae, syzygium polyanthum (wight), blood glucose.

References


Association American Diabetes. Updates to the Standards of Medical Care in Diabetes-2018. Diabetes Care. 2018;41(9):2045-2047. doi:10.2337/dc18-su09

Widiyoga CR, Saichudin, Andiana O. Hubungan Tingkat Pengetahuan tentang Penyakit Diabetes Melitus pada Penderita terhadap Pengaturan Pola Makan dan Physical Activity. Sport Science and Health. 2020;2(2):152-161.

Azis WA, Muriman LY, Burhan SR. Hubungan Tingkat Pengetahuan dengan Gaya Hidup Penderita Diabetes Mellitus. J Penelit Perawat Prof. 2020;2(1):105-114.

Soelistijo S, Novida H, Rudijanto A, et al. Konsesus Pengelolaan Dan Pencegahan Diabetes Melitus Tipe2 Di Indonesia 2015. Jakarta: PB Perkeni, 2015.

Lutfiasari N. Keanekaragaman Spesies Tumbuhan Famili Myrtaceae Di Hutan Pantai Tabanio , Kecamatan Takisung , Kabupaten Tanah Laut Species Diversity of Family Myrtaceae in Tabanio Coast Forest , Takisung District , Tanah Laut Regency. 2018;3(April):186-190.

Silalahi M. Syzygium polyanthum (Wight) Walp.(Botani, Metabolit Sekunder dan Pemanfaatan). J Din Pendidik. 2017;10(1):187-202.

Sukmawati, Kosman R, Saharuddin N. Kombinasi Ekstrak Etanol Daun Kemangi (Ocimum bacilicum L.) Dan Daun Salam (Syzygium polyanthum (Wight) Walp) Sebagai Antiinflamasi Pada Tikus (Rattus norvegicus) Jantan. As-syifaa. 2018;10(01):1-10.

Renggana H, Hadisaputri YE, Subarnas A, et al. Jurnal Ilmiah Farmako Bahari Myrtaceae Anticancer Activities. Published online 2018:23-32.

Nadifah F, Fatimah S, Susanti L. Pengaruh Infusa Daun Jambu Biji (Psidium guajava Linn.) Terhadap Pertumbuhan Bakteri Escherichia coli Secara In Vitro. J Heal. 2015;2(2):65.

Setyowati E, Retnowati E, Rosita V, Rosiana LH. Skrining Aktivitas Antibakteri Tanaman Famili Myrtaceae Terhadap Pseudomonas Aeruginosa. Indones J Farm. 2019;4(1):6-11.

Wulandari A, Sudiastuti, Sudrajat. Efek hipoglikemik ekstrak etanol batang karamunting (Melastoma malabathricum) terhadap kadar gula darah dan perubahan struktur mikroanatomi pankreas mencit (Mus musculus l.) diabetesi. Bioprospek. 2016;11(2):48-52.

Hasibuan R, Ilyas S, Hanum S. Effect of leaf extract haramonting (Rhodomyrtus tomentosa) to lower blood sugar levels in mice induced by alloxan. Int J PharmTech Res. 2015;8(6):284-291.

Sinata N, Arifin H. Antidiabetes dari Fraksi Air Daun Karamunting (Rhodomyrtus tomentosa (Ait.) Hassk.) Terhadap Kadar Glukosa Darah Mencit Diabetes. J Sains Farm Klin. 2016;3(1):72.

Liem S, Yuliet Y, Khumaidi A. Uji aktivitas antidiabetes kombinasi glibenklamid dan ekstrak daun salam (Syzygium polyanthum Wight.) terhadap mencit (Mus musculus) yang diinduksi aloksan. J Farm Galen (Galenika J Pharmacy). 2015;1(1):42-47.

Wahjuni S, Wita IW. Hypoglycemic and antioxidant effects of Syzygium polyanthum leaves extract on alloxan induced hyperglycemic Wistar Rats. Bali Med J. 2017;6(3):113.

Mustika DY, NA Z, Harris A, Rinidar, Asmilia N, Hasan M. Effect of Ethanol Extract Jamblang Leaves (Syzygium cumini) against Blood Glucose Levels In Rats (Rattus norvegicus) Diabetes Mellitus Induced Streptozotocin. Jimvet. 2017;01(4):620-624.

Indrisari M, Zulham. Antihyperglycemic Activity of Various Extracts of Jamblang (Syzygium cumini) on White Rat. J Pharm Med Sci. 2017;2(2):81-84.

Purwandari R, Subagiyo S, Wibowo T. Uji Aktivitas Antioksidan Ekstrak Daun Jambu Biji. Walisongo J Chem. 2018;1(2):66.

Guspratiwi R, Mursyida E, Yulinar. Pengaruh Ekstrak Etanol 96 % Daun Jambu Biji ( Psidium Guajava L .) Terhadap Kadar Gula Darah Tikus Wistar Jantan ( Rattus Novergicus ) Yang Diinduksi Aloksan. Collaborative Medical Journal (CMJ). 2019;2(3):106-116.

Azizah A, Suswati I, Agustin SM. Efek Anti Mikroba Ekstrak Bunga Cengkeh (Syzygium aromaticum) Terhadap Methicillin-Resistant Staphylococcus Aureus (MRSA) Secara in Vitro. Saintika Med. 2018;13(1):31.

Hasmar WN, Herowati R, Pamudji G. Perbaikan Stres Oksidatif Ekstrak Etanol dan Fraksi Bunga Cengkeh ( Syzygium aromaticum L .) pada Tikus yang Diinduksi. Sainstech Farma. 2020;13(1):27-32.

Utami SW, Sudarma IM, Hamdin CD. Efek Pemberian Eugenol Isolat Bunga Cengkeh (Syzygium aromaticum) terhadap Histologi Pankreas Tikus Diabetes. J Ilmu Kefarmasian Indones. 2019;17(2):160.

Sundhani E, Syarifah DCN, Zumrohani LR, Nurulita NA. The Effect Of Adam Hawa (Rhoeo discolor) And Pucuk Merah (Syzygium campanulatum Korth.) Leaves Ethanolic Extract To Decrease Blood Glucose Level On Rats Male Strain Wistar Induced With Glucose. PHARMACY. 2016;13(02):137-149.

Syilfia Hasti, Emrizal FS. Antidiabetic Activities Test Of N-Hexana Ekstract Of Syzygium myrtifolium Walp. Leaves On White Mice Diabetes. PHARMACY. 2016;13(02):172-181.

Parisa N, Tamzil NS, Handayati Harahap D, et al. The effect of Leaf Salam Extracts (Syzygium polyanthum) in diabetes mellitus therapy on wistar albino rats. J Phys Conf Ser. 2019;1246(1).

Province S. Ournal of. Asian J Chem. 2014;26(18):6097-6100.

Ahmed KZ, Naeem S, Noo A. Determination of Phenolic Compounds in Callistemon viminalis L. and Its Role in Amelioration of Hyperglycemia in AlloxanInduced Diabetic Rats. Ann Jinnah Sindh Med Uni. 2018;4(1):4-8.

Suwandi DW, Perdana F. Antihyperuricemia Activity of Ethanol Extract and Fractions of Rose Guava (Syzygium jambos L.,) in Swiss Webster Male. J Ilm Farm Bahari. 2018;9(1):35-44.

Prastiwi M, Kartika R, Hindryawati N. Antihyperglycemic Activity Of Jambu Mawar Leaves Extract (Syzygium jambos (L.) Aston) On Male Rabbit Alloxant Induced. J At. 2019;04(1):14-16.

Sada JT, Tanjung RHR. Keragaman Tumbuhan Obat Tradisional di Kampung Nansfori Distrik Supiori Utara, Kabupaten Supiori-Papua. J Biol Papua. 2010;2(2):39-46.

Husna F, Suyatna FD, Arozal W, Purwaningsih EH. Model Hewan Coba pada Penelitian Diabetes. Pharm Sci Res. 2019;6(3):131-141.

Wahyulianingsih W, Handayani S, Malik A. Penetapan Kadar Flavonoid Total Ekstrak Daun Cengkeh (Syzygium aromaticum (L.) Merr & Perry). J Fitofarmaka Indones. 2016;3(2):188-193.

Carolus FP, Wewengkang S. Uji Efektivitas Ekstrak Kulit Batang Jambu Mete (Anacardium Occidentale L.) Terhadap Penurunan Kadar Glukosa Darah Pada Tikus Putih Jantan Galur Wistar (Rattus norvegicus) Yang Diinduksi Aloksan. Pharmacon. 2014;3(3):204-210.




DOI: https://doi.org/10.56711/jifa.v13i1.762

Refbacks

  • There are currently no refbacks.


Indexed by:

     

ISSN: 2085-4714 | e-ISSN: 2502-9444

Editor's Address:

Faculty of Pharmacy, Univeristas Muslim Indonesia
2nd Campus of UMI: Jl. Urip Sumoharjo km. 5 , Makassar, South Sulawesi, Indonesia

E-mail: jurnal.farmasi@umi.ac.id

View My Stats